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Discovery of hPRDX5-based peptide inhibitors blocking PD-1/PD-L1 interaction through in silico proteolysis and rational design.
Zou, Sen; Liu, Juanjuan; Sun, Zhengyang; Feng, Xiao; Wang, Zhongbo; Jin, Yuanyuan; Yang, Zhaoyong.
Afiliação
  • Zou S; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, No. 1 Tiantanxili, Dongcheng District, Beijing, 100050, China.
  • Liu J; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, No. 1 Tiantanxili, Dongcheng District, Beijing, 100050, China.
  • Sun Z; North China University of Science and Technology, Tangshan, China.
  • Feng X; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, No. 1 Tiantanxili, Dongcheng District, Beijing, 100050, China.
  • Wang Z; North China University of Science and Technology, Tangshan, China.
  • Jin Y; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, No. 1 Tiantanxili, Dongcheng District, Beijing, 100050, China. jinyuanyuan@imb.pumc.edu.cn.
  • Yang Z; NHC Key Laboratory of Biotechnology of Antibiotics, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences, No. 1 Tiantanxili, Dongcheng District, Beijing, 100050, China. zhaoyongy@imb.pumc.edu.cn.
Cancer Chemother Pharmacol ; 85(1): 185-193, 2020 01.
Article em En | MEDLINE | ID: mdl-31745591
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Desenho de Fármacos / Neoplasias do Colo / Peroxirredoxinas / Domínios e Motivos de Interação entre Proteínas / Descoberta de Drogas / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fragmentos de Peptídeos / Desenho de Fármacos / Neoplasias do Colo / Peroxirredoxinas / Domínios e Motivos de Interação entre Proteínas / Descoberta de Drogas / Antígeno B7-H1 / Receptor de Morte Celular Programada 1 Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article