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CIDE family proteins control lipid homeostasis and the development of metabolic diseases.
Chen, Feng-Jung; Yin, Yesheng; Chua, Boon Tin; Li, Peng.
Afiliação
  • Chen FJ; Institute of Metabolism and Integrative Biology, the Human Phenome Institute, Fudan University, and Zhongshan Hospital of Fudan University, Shanghai, China.
  • Yin Y; Institute of Metabolism and Integrative Biology, the Human Phenome Institute, Fudan University, and Zhongshan Hospital of Fudan University, Shanghai, China.
  • Chua BT; Institute of Metabolism and Integrative Biology, the Human Phenome Institute, Fudan University, and Zhongshan Hospital of Fudan University, Shanghai, China.
  • Li P; State Key Laboratory of Membrane Biology and Tsinghua-Peking Center for Life Sciences, Beijing Advanced Innovation Center for Structural Biology, School of Life Sciences, Tsinghua University, Beijing, China.
Traffic ; 21(1): 94-105, 2020 01.
Article em En | MEDLINE | ID: mdl-31746121
Dysregulation of lipid homeostasis leads to the development of metabolic disorders including obesity, diabetes, cardiovascular disease and cancer. Lipid droplets (LDs) are subcellular organelles vital in the maintenance of lipid homeostasis by coordinating lipid synthesis, lipid storage, lipid secretion and lipolysis. Under fed condition, free fatty acids (FFAs) are remodeled and esterified into neutral lipids by lipogenesis and stored in the LDs. The lipid storage capacity of LDs is controlled by its growth via local lipid synthesis or by LD fusion. During fasting, neutral lipids are hydrolyzed by lipolysis, released as FFAs and secreted to meet energy demand. Cell death-inducing DNA fragmentation factor alpha (DFFA)-like effector (CIDE) family proteins composed of Cidea, Cideb and Cidec/Fsp27 are ER- and LD-associated proteins and have emerged as important regulators of lipid homeostasis. Notably, when localized on the LDs, CIDE proteins enrich at the LD-LD contact sites (LDCSs) and control LD fusion and growth. Here, we summarize these recent advances made on the role of CIDE proteins in the regulation of lipid metabolism with a particular focus on the molecular mechanisms underlying CIDE-mediated LD fusion and growth.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Reguladoras de Apoptose / Doenças Metabólicas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Proteínas Reguladoras de Apoptose / Doenças Metabólicas Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article