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Alterations in Blood Chemistry Levels Associated With Nipah Virus Disease in the Syrian Hamster Model.
Genzer, Sarah C; Welch, Stephen R; Scholte, Florine E M; Harmon, Jessica R; Coleman-McCray, JoAnn D; Lo, Michael K; Montgomery, Joel M; Nichol, Stuart T; Spiropoulou, Christina F; Spengler, Jessica R.
Afiliação
  • Genzer SC; Comparative Medicine Branch, Division of Scientific Resources, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Welch SR; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Scholte FEM; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Harmon JR; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Coleman-McCray JD; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Lo MK; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Montgomery JM; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Nichol ST; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Spiropoulou CF; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Spengler JR; Viral Special Pathogens Branch, Division of High-Consequence Pathogens and Pathology, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
J Infect Dis ; 221(Suppl 4): S454-S459, 2020 05 11.
Article em En | MEDLINE | ID: mdl-31747016
ABSTRACT
Nipah virus (NiV; family Paramyxoviridae, genus Henipavirus) infection can cause severe respiratory and neurological disease in humans. The pathophysiology of disease is not fully understood, and it may vary by presentation and clinical course. In this study, we investigate changes in blood chemistry in NiV-infected Syrian hamsters that survived or succumbed to disease. Increased sodium and magnesium and decreased albumin and lactate levels were detected in animals euthanized with severe clinical disease compared with mock-infected controls. When subjects were grouped by clinical syndrome, additional trends were discernable, highlighting changes associated with either respiratory or neurological disease.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sódio / Albumina Sérica / Vírus Nipah / Infecções por Henipavirus / Magnésio Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Sódio / Albumina Sérica / Vírus Nipah / Infecções por Henipavirus / Magnésio Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article