Your browser doesn't support javascript.
loading
Nasal epithelial cells to assess in vitro immune responses to respiratory virus infection in pregnant women with asthma.
Vanders, Rebecca L; Hsu, Alan; Gibson, Peter G; Murphy, Vanessa E; Wark, Peter A B.
Afiliação
  • Vanders RL; Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia. rebecca.vanders@newcastle.edu.au.
  • Hsu A; Viruses, Infection & Immunity, Vaccines & Asthma (VIVA), Hunter Medical Research Institute, Newcastle, NSW, Australia. rebecca.vanders@newcastle.edu.au.
  • Gibson PG; Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.
  • Murphy VE; Viruses, Infection & Immunity, Vaccines & Asthma (VIVA), Hunter Medical Research Institute, Newcastle, NSW, Australia.
  • Wark PAB; Priority Research Centre for Healthy Lungs, The University of Newcastle, Newcastle, NSW, Australia.
Respir Res ; 20(1): 259, 2019 Nov 20.
Article em En | MEDLINE | ID: mdl-31747925
Respiratory virus-induced asthma exacerbations occur frequently during pregnancy and are associated with adverse outcomes for mother and child. Primary nasal epithelial cells (pNECs) provide a useful method to study immune responses in pregnancy. pNECs were obtained by nasal brushings from pregnant and non-pregnant women with and without asthma. pNECS were infected in vitro with major group Rhinovirus 43 (RV43) and seasonal influenza (H3N2). Following infection, pNECs showed measurable quantities of interferon (IFN)-λ, IL-1ß, IL-8, IP-10 and MIP1-α. pNECs provide a safe and effective method for studying respiratory epithelial cell responses during pregnancy.
Assuntos
Palavras-chave

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Asma / Rhinovirus / Vírus da Influenza A Subtipo H3N2 / Imunidade Celular / Mucosa Nasal Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Complicações Infecciosas na Gravidez / Asma / Rhinovirus / Vírus da Influenza A Subtipo H3N2 / Imunidade Celular / Mucosa Nasal Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article