Carnosic Acid Attenuates Cadmium Induced Nephrotoxicity by Inhibiting Oxidative Stress, Promoting Nrf2/HO-1 Signalling and Impairing TGF-ß1/Smad/Collagen IV Signalling.

Das, Sonjit; Dewanjee, Saikat; Dua, Tarun K; Joardar, Swarnalata; Chakraborty, Pratik; Bhowmick, Shovonlal; Saha, Achintya; Bhattacharjee, Simanta; De Feo, Vincenzo

Das, Sonjit; Dewanjee, Saikat; Dua, Tarun K; Joardar, Swarnalata; Chakraborty, Pratik; Bhowmick, Shovonlal; Saha, Achintya; Bhattacharjee, Simanta; De Feo, Vincenzo.

Afiliação

Das S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Dewanjee S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Dua TK; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Joardar S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Chakraborty P; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
Bhowmick S; Department of Chemical Technology, University of Calcutta, Kolkata 700009, India.
Saha A; Department of Chemical Technology, University of Calcutta, Kolkata 700009, India.
Bhattacharjee S; Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata 700032, India.
De Feo V; Department of Pharmacy, University of Salerno, 84084 Fisciano, Italy.

Molecules ; 24(22)2019 Nov 18.

Article em En | MEDLINE | ID: mdl-31752142

Assuntos

Abietanos/farmacologia; Cloreto de Cádmio/antagonistas & inibidores; Cloreto de Cádmio/toxicidade; Rim/efeitos dos fármacos; Animais; Antioxidantes/farmacologia; Cádmio/farmacologia; Linhagem Celular; Colágeno Tipo IV/metabolismo; Heme Oxigenase-1/metabolismo; Rim/metabolismo; Rim/patologia; Camundongos; Simulação de Acoplamento Molecular; Fator 2 Relacionado a NF-E2/metabolismo; Estresse Oxidativo/efeitos dos fármacos; Transdução de Sinais/efeitos dos fármacos; Proteínas Smad/metabolismo; Fator de Crescimento Transformador beta1/metabolismo

Palavras-chave

antioxidant; cadmium chloride; carnosic acid; molecular docking; oxidative stress

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cloreto de Cádmio / Abietanos / Rim Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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