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Carotid Plaque With High-Risk Features in Embolic Stroke of Undetermined Source: Systematic Review and Meta-Analysis.
Kamtchum-Tatuene, Joseph; Wilman, Alan; Saqqur, Maher; Shuaib, Ashfaq; Jickling, Glen C.
Afiliação
  • Kamtchum-Tatuene J; From the Neuroscience and Mental Health Institute, Faculty of Medicine and Dentistry (J.K.-T.), University of Alberta, Edmonton, Canada.
  • Wilman A; Department of Biomedical Engineering (A.W.), University of Alberta, Edmonton, Canada.
  • Saqqur M; Division of Neurology, Department of Medicine (M.S., A.S., G.C.J.), University of Alberta, Edmonton, Canada.
  • Shuaib A; Division of Neurology, Department of Medicine (M.S., A.S., G.C.J.), University of Alberta, Edmonton, Canada.
  • Jickling GC; Division of Neurology, Department of Medicine (M.S., A.S., G.C.J.), University of Alberta, Edmonton, Canada.
Stroke ; 51(1): 311-314, 2020 01.
Article em En | MEDLINE | ID: mdl-31752616
Background and Purpose- An ipsilateral mild carotid stenosis, defined as plaque with <50% luminal narrowing, is identified in nearly 40% of patients with embolic stroke of undetermined source and could represent an unrecognized source of atheroembolism. We aimed to summarize data about the frequency of mild carotid stenosis with high-risk features in embolic stroke of undetermined source. Methods- We searched Pubmed and Ovid-Embase for studies reporting carotid plaque imaging features in embolic stroke of undetermined source. The prevalence of ipsilateral and contralateral mild carotid stenosis with high-risk features was pooled using random-effect meta-analysis. Results- Eight studies enrolling 323 participants were included. The prevalence of mild carotid stenosis with high-risk features in the ipsilateral carotid was 32.5% (95% CI, 25.3-40.2) compared with 4.6% (95% CI, 0.1-13.1) in the contralateral carotid. The odds ratio of finding a plaque with high-risk features in the ipsilateral versus the contralateral carotid was 5.5 (95% CI, 2.5-12.0). Conclusions- Plaques with high-risk features are 5 times more prevalent in the ipsilateral compared with the contralateral carotid in embolic stroke of undetermined source, suggesting a relationship to stroke risk.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estenose das Carótidas / Embolia Intracraniana / Placa Aterosclerótica Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estenose das Carótidas / Embolia Intracraniana / Placa Aterosclerótica Tipo de estudo: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Aged / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article