Oxyresveratrol drives caspase-independent apoptosis-like cell death in MDA-MB-231 breast cancer cells through the induction of ROS.

Sunilkumar, Damu; Drishya, G; Chandrasekharan, Aneesh; Shaji, Sanu K; Bose, Chinchu; Jossart, Jennifer; Perry, J Jefferson P; Mishra, Nandita; Kumar, Geetha B; Nair, Bipin G

Sunilkumar, Damu; Drishya, G; Chandrasekharan, Aneesh; Shaji, Sanu K; Bose, Chinchu; Jossart, Jennifer; Perry, J Jefferson P; Mishra, Nandita; Kumar, Geetha B; Nair, Bipin G.

Afiliação

Sunilkumar D; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India. Electronic address: damubiotec@gmail.com.
Drishya G; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India.
Chandrasekharan A; Cancer Research Program, Rajiv Gandhi Centre for Biotechnology, Poojappura, Thycaud P.O., Thiruvananthapuram, Kerala 695014, India.
Shaji SK; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India.
Bose C; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India.
Jossart J; Department of Biochemistry, University of California, Riverside, Riverside, CA 92521,USA.
Perry JJP; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India; Department of Biochemistry, University of California, Riverside, Riverside, CA 92521,USA.
Mishra N; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India.
Kumar GB; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India.
Nair BG; Amrita School of Biotechnology, Amrita Vishwa Vidyapeetham, Amritapuri, Clappana P.O., Kollam, Kerala 690525, India. Electronic address: bipin@am.amrita.edu.

Biochem Pharmacol ; 173: 113724, 2020 03.

Article em En | MEDLINE | ID: mdl-31756327

Assuntos

Apoptose/efeitos dos fármacos; Neoplasias da Mama/metabolismo; Caspases/metabolismo; Mitocôndrias/efeitos dos fármacos; Extratos Vegetais/farmacologia; Espécies Reativas de Oxigênio/metabolismo; Estilbenos/farmacologia; Antineoplásicos/química; Antineoplásicos/metabolismo; Antineoplásicos/farmacologia; Neoplasias da Mama/patologia; Caspase 3/química; Caspase 3/metabolismo; Caspases/química; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Feminino; Humanos; Potencial da Membrana Mitocondrial/efeitos dos fármacos; Mitocôndrias/metabolismo; Simulação de Acoplamento Molecular; Extratos Vegetais/química; Extratos Vegetais/metabolismo; Ligação Proteica; Estilbenos/química; Estilbenos/metabolismo

Palavras-chave

Apoptosis inducing factor; Breast cancer; Caspase-independent cell death; Oxyresveratrol; Reactive oxygen species

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Estilbenos / Neoplasias da Mama / Extratos Vegetais / Espécies Reativas de Oxigênio / Apoptose / Caspases / Mitocôndrias Tipo de estudo: Prognostic_studies Limite: Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google