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Association of magnesium consumption with type 2 diabetes and glucose metabolism: A systematic review and pooled study with trial sequential analysis.
Zhao, Binghao; Deng, Huan; Li, Bo; Chen, Lian; Zou, Fang; Hu, Lei; Wei, Yiping; Zhang, Wenxiong.
Afiliação
  • Zhao B; Department of Thoracic Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Deng H; Department of Neurosurgery, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
  • Li B; Department of Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Chen L; Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Zou F; Department of Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Hu L; Jiangxi Medical College, Nanchang University, Nanchang, China.
  • Wei Y; Department of Endocrinology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
  • Zhang W; Jiangxi Medical College, Nanchang University, Nanchang, China.
Diabetes Metab Res Rev ; 36(3): e3243, 2020 03.
Article em En | MEDLINE | ID: mdl-31758631
ABSTRACT
Prevention of type 2 diabetes (T2D) with diet or diet supplementation is challenging. This article aims to draw conclusive associations between magnesium intake and T2D incidence and evaluate the effect of magnesium supplementation on glucose metabolism. Databases were searched for related articles from inception to May 15, 2019. Prospective cohort studies investigating the relevant relationship as well as randomized controlled trials (RCTs) assessing the effect of magnesium supplementation were eligible. We conducted trial sequential analysis (TSA) to prove the sufficiency of the current evidence. Twenty-six publications involving 35 cohorts were included in the analysis. Compared to the lowest magnesium intake, the highest level was associated with a 22% lower risk for T2D; the risk was reduced by 6% for each 100 mg increment in daily magnesium intake. Additional analysis of 26 RCTs (1168 participants) was performed, revealing that magnesium supplementation significantly reduced the fasting plasma glucose (FPG) level (SMD, -0.32 [95% CI, -0.59 to -0.05], 2-hour oral glucose tolerance test (2-h OGTT) result (SMD, -0.30 [-0.58 to -0.02]), fasting insulin level (SMD, -0.17 [-0.30 to -0.04]), homeostatic model assessment-insulin resistance (HOMA-IR) score (SMD, -0.41 [-0.71 to -0.11]), triglyceride (TG) level, systolic blood pressure (SBP) and diastolic blood pressure (DBP). TSA showed an inverse association, with most benefits of magnesium supplementation on glucose metabolism being stable. In conclusion, magnesium intake has an inverse dose-response association with T2D incidence, and supplementation appears to be advisable in terms of glucose parameters in T2D/high-risk individuals.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Diabetes Mellitus Tipo 2 / Magnésio Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Glicemia / Diabetes Mellitus Tipo 2 / Magnésio Tipo de estudo: Clinical_trials / Observational_studies / Prognostic_studies / Risk_factors_studies / Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article