Pulmonary Alveolar Microlithiasis in Children Less than 5 Years of Age.
J Pediatr
; 217: 158-164.e1, 2020 02.
Article
em En
| MEDLINE
| ID: mdl-31761429
ABSTRACT
OBJECTIVE:
To collect all published cases up to January 2019 of pulmonary alveolar microlithiasis (PAM) in patients age 5 years and under and to compare their characteristics with those of the 1022 cases in the most recent all-age cohort published in 2015. STUDYDESIGN:
We identified 28 cases of PAM worldwide in children age 5 years and under, accounting for only 2%-3% of all cases.RESULTS:
Children seem more frequently symptomatic, notably with more cough and severe acute respiratory failure, but had no reported extrapulmonary manifestation. Children with PAM evidenced less typical radiologic findings, with frequent ground glass opacities not reported in adult cases and milder calcifications as less frequent, smaller, and mainly restricted to the lower lobes.CONCLUSIONS:
PAM remains an uncommon diagnosis in young children, as symptoms and radiologic findings are less specific. Physicians should be aware to look for calcifications in chest computed tomography at mediastinal window and avoid elution of the bronchoalveolar lavage to find microliths. Collecting longitudinal data through an international registry would help in characterizing PAM to predict disease progression and plan lung transplantation.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Alvéolos Pulmonares
/
Calcinose
/
Tomografia Computadorizada por Raios X
/
Doenças Genéticas Inatas
/
Pneumopatias
Tipo de estudo:
Diagnostic_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Child, preschool
/
Humans
/
Infant
/
Male
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article