Transplacental Gene Delivery (TPGD) as a Noninvasive Tool for Fetal Gene Manipulation in Mice.

Nakamura, Shingo; Watanabe, Satoshi; Ando, Naoko; Ishihara, Masayuki; Sato, Masahiro

Nakamura, Shingo; Watanabe, Satoshi; Ando, Naoko; Ishihara, Masayuki; Sato, Masahiro.

Afiliação

Nakamura S; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Watanabe S; Animal Genome Unit, Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization (NARO), Tsukuba, Ibaraki 305-0901, Japan.
Ando N; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Ishihara M; Division of Biomedical Engineering, National Defense Medical College Research Institute, Saitama 359-8513, Japan.
Sato M; Section of Gene Expression Regulation, Frontier Science Research Center, Kagoshima University, Kagoshima 890-8544, Japan.

Int J Mol Sci ; 20(23)2019 Nov 25.

Article em En | MEDLINE | ID: mdl-31775372

Assuntos

Sistemas CRISPR-Cas; DNA/administração & dosagem; Feto/metabolismo; Edição de Genes; Marcação de Genes; Terapia Genética; Placenta/metabolismo; Animais; Feminino; Engenharia Genética; Camundongos; Gravidez

Palavras-chave

CRISPR/Cas9; TPGD for acquiring genome-edited fetuses (TPGD-GEF); fetal gene therapy; genome editing; transplacental gene delivery (TPGD)

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Placenta / DNA / Terapia Genética / Marcação de Genes / Feto / Sistemas CRISPR-Cas / Edição de Genes Limite: Animals / Pregnancy Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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