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Autophagy in Reproduction.
Gao, Hui; Khawar, Muhammad Babar; Li, Wei.
Afiliação
  • Gao H; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.
  • Khawar MB; State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, 1 Beichen West Road, Chaoyang District, Beijing, 100101, China.
  • Li W; University of Chinese Academy of Sciences, Beijing, 100049, China.
Adv Exp Med Biol ; 1206: 453-468, 2019.
Article em En | MEDLINE | ID: mdl-31776998
Autophagy, a major degradation/recycling pathway, plays an essential role in cellular homeostasis maintenance, cell fate decision, and reproductive development. During reproduction, sperms and eggs, the specialized haploid gametes produced by the meiotic process of the germ cells in male and female respectively, are fused to form a new zygote that develops into fetus through embryogenesis and maternal-fetal crosstalk. Researches carried out in the past few years have proved that autophagy plays a key role in the regulation of reproduction process, and blockage of autophagy process likely contributes to reproductive abnormalities and even infertility. Here we summerize the recent progress in exploring the functional roles of autophagy in reproductive processes, such as spermatogenesis, folliculogenesis, fertilization, embryogenesis, and maternal-fetal crosstalk, in both animals and plants.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reprodução / Autofagia Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Reprodução / Autofagia Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2019 Tipo de documento: Article