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Loss of tissue-nonspecific alkaline phosphatase (TNAP) enzyme activity in cerebral microvessels is coupled to persistent neuroinflammation and behavioral deficits in late sepsis.
Nwafor, Divine C; Chakraborty, Sreeparna; Brichacek, Allison L; Jun, Sujung; Gambill, Catheryne A; Wang, Wei; Engler-Chiurazzi, Elizabeth B; Dakhlallah, Duaa; Pinkerton, Anthony B; Millán, José Luis; Benkovic, Stanley A; Brown, Candice M.
Afiliação
  • Nwafor DC; Department of Neuroscience, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: dnwafor@mix.wvu.edu.
  • Chakraborty S; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University Health Science Center, Morgantown, WV 26506, USA.
  • Brichacek AL; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: alb0037@mix.wvu.edu.
  • Jun S; Wilmer Eye Institute, John Hopkins University School of Medicine, Baltimore, MD 21231, USA. Electronic address: sjun6@jhmi.edu.
  • Gambill CA; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: cag0030@mix.wvu.edu.
  • Wang W; Department of Neuroscience, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: wgwang@hsc.wvu.edu.
  • Engler-Chiurazzi EB; Department of Neuroscience, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: elengler@hsc.wvu.edu.
  • Dakhlallah D; Department of Neuroscience, West Virginia University Health Science Center, Morgantown, WV 26506, USA; Cancer Institute, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: duaa.dakhlallah@hsc.wvu.edu.
  • Pinkerton AB; Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: apinkerton@sbpdiscovery.org.
  • Millán JL; Sanford-Burnham Prebys Medical Discovery Institute, La Jolla, CA 92037, USA. Electronic address: millan@sbpdiscovery.org.
  • Benkovic SA; Department of Neuroscience, West Virginia University Health Science Center, Morgantown, WV 26506, USA.
  • Brown CM; Department of Neuroscience, West Virginia University Health Science Center, Morgantown, WV 26506, USA; Department of Microbiology, Immunology, and Cell Biology, School of Medicine, West Virginia University Health Science Center, Morgantown, WV 26506, USA. Electronic address: cdbrown2@hsc.wvu.edu.
Brain Behav Immun ; 84: 115-131, 2020 02.
Article em En | MEDLINE | ID: mdl-31778743
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Sepse / Fosfatase Alcalina / Microvasos / Inflamação Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Sepse / Fosfatase Alcalina / Microvasos / Inflamação Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article