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Structural Aspects of Carbohydrate Recognition Mechanisms of C-Type Lectins.
Nagae, Masamichi; Yamaguchi, Yoshiki.
Afiliação
  • Nagae M; Department of Pharmaceutical Sciences, The University of Tokyo, Hongo 7-3-1, Bunkyo-Ku, Tokyo, 113-0033, Japan. mnagae@mol.f.u-tokyo.ac.jp.
  • Yamaguchi Y; Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University, Miyagi, 981-8558, Japan. yyoshiki@tohoku-mpu.ac.jp.
Curr Top Microbiol Immunol ; 429: 147-176, 2020.
Article em En | MEDLINE | ID: mdl-31781867
Carbohydrate recognition is an essential function occurring in all living organisms. Lectins are carbohydrate-binding proteins and are classified into several families. In mammals, Ca2+-dependent C-type lectins, such as ß-galactoside-binding galectin and sialic acid-binding siglec, play crucial roles in the immune response and homeostasis. C-type lectins are abundant and diverse in animals. Their immunological activities include lymphocyte homing, pathogen recognition, and clearance of apoptotic bodies. C-type lectin domains are composed of 110-130 amino acid residues with highly conserved structural folds. Remarkably, individual lectins can accept a wide variety of sugar ligands and can distinguish subtle structural differences in closely related ligands. In addition, several C-type lectin-like proteins specifically bind to carbohydrate ligands in Ca2+-independent ways. The accumulated 3D structural evidence clarifies the unexpected structural versatility of C-type lectins underlying the variety of ligand binding modes. In this issue, we focus on the structural aspects of carbohydrate recognition mechanisms of C-type lectins and C-type lectin-like proteins.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carboidratos / Lectinas Tipo C Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Carboidratos / Lectinas Tipo C Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article