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Advances in genetics toward identifying pathogenic cell states of rheumatoid arthritis.
Amariuta, Tiffany; Luo, Yang; Knevel, Rachel; Okada, Yukinori; Raychaudhuri, Soumya.
Afiliação
  • Amariuta T; Center for Data Sciences, Harvard Medical School, Boston, MA, USA.
  • Luo Y; Divisions of Genetics and Rheumatology, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
  • Knevel R; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
  • Okada Y; Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA.
  • Raychaudhuri S; Graduate School of Arts and Sciences, Harvard University, Boston, MA, USA.
Immunol Rev ; 294(1): 188-204, 2020 03.
Article em En | MEDLINE | ID: mdl-31782165
Rheumatoid arthritis (RA) risk has a large genetic component (~60%) that is still not fully understood. This has hampered the design of effective treatments that could promise lifelong remission. RA is a polygenic disease with 106 known genome-wide significant associated loci and thousands of small effect causal variants. Our current understanding of RA risk has suggested cell-type-specific contexts for causal variants, implicating CD4 + effector memory T cells, as well as monocytes, B cells and stromal fibroblasts. While these cellular states and categories are still mechanistically broad, future studies may identify causal cell subpopulations. These efforts are propelled by advances in single cell profiling. Identification of causal cell subpopulations may accelerate therapeutic intervention to achieve lifelong remission.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Linfócitos B / Monócitos / Linfócitos T CD4-Positivos / Fibroblastos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Linfócitos B / Monócitos / Linfócitos T CD4-Positivos / Fibroblastos Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article