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Functions and mechanism of noncoding RNA in the somatic cells of the testis.
Li, Chunjie; Chen, Baiqi; Wang, Jing.
Afiliação
  • Li C; Basic Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
  • Chen B; School of Public Health, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
  • Wang J; Basic Medical College, Nanchang University, Nanchang, Jiangxi, People's Republic of China.
Zygote ; 28(2): 87-92, 2020 Apr.
Article em En | MEDLINE | ID: mdl-31787116
ABSTRACT
ncRNAs are involved in numerous biological processes by regulating gene expression and cell stability. Studies have shown that ncRNAs also contribute to spermatogenesis. Leydig cells (LCs) and Sertoli cells (SCs) are somatic cells of the testis that support spermatogenesis and are vital to male fertility. In this review, we summarized the findings from studies on ncRNAs in SCs and LCs. In SCs, ncRNAs play key roles in phagocytosis, immunoprotection and development of SCs. In LCs, ncRNAs are involved in steroidogenesis, in particular production of testosterone as well as development of LCs. Here, we discuss the possible target genes and functions of ncRNAs in both types of cells. These ncRNAs regulate the expression of target genes or mRNA coding sequence regions, resulting in a chain reaction that influences cell function. In addition, microRNAs, lncRNAs, piRNA-like RNAs (pilRNAs) and natural antisense transcripts (NATs) are discussed in this review. In summary, we suggest that these ncRNAs might act in coordination to control spermatogenesis and maintain the environmental homeostasis of the testis.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / RNA Longo não Codificante Limite: Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Testículo / RNA Longo não Codificante Limite: Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article