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A covalent small molecule inhibitor of glutamate-oxaloacetate transaminase 1 impairs pancreatic cancer growth.
Yoshida, Tomohiro; Yamasaki, Shingo; Kaneko, Osamu; Taoka, Naofumi; Tomimoto, Yusuke; Namatame, Ichiji; Yahata, Toshiko; Kuromitsu, Sadao; Cantley, Lewis C; Lyssiotis, Costas A.
Afiliação
  • Yoshida T; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Yamasaki S; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Kaneko O; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Taoka N; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Tomimoto Y; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Namatame I; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Yahata T; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Kuromitsu S; Drug Discovery Research, Astellas Pharma Inc., 21 Miyukigaoka, Tsukuba-shi, Ibaraki, 305-8585, Japan.
  • Cantley LC; Meyer Cancer Center, Department of Medicine, Weill Cornell Medical College, New York, NY, 10065, United States.
  • Lyssiotis CA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, 48109, United States; Department of Internal Medicine, Division of Gastroenterology, University of Michigan, Ann Arbor, MI, 48109, United States; Rogel Cancer Center, University of Michigan, Ann Arbor, MI, 481
Biochem Biophys Res Commun ; 522(3): 633-638, 2020 02 12.
Article em En | MEDLINE | ID: mdl-31787239
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Pirazóis / Carcinoma Ductal Pancreático / Aspartato Aminotransferase Citoplasmática / Inibidores Enzimáticos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Pirazóis / Carcinoma Ductal Pancreático / Aspartato Aminotransferase Citoplasmática / Inibidores Enzimáticos Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article