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The phosphodiesterase 10 inhibitor papaverine exerts anti-inflammatory and neuroprotective effects via the PKA signaling pathway in neuroinflammation and Parkinson's disease mouse models.
Lee, Yu-Young; Park, Jin-Sun; Leem, Yea-Hyun; Park, Jung-Eun; Kim, Do-Yeon; Choi, Youn-Hee; Park, Eun-Mi; Kang, Jihee Lee; Kim, Hee-Sun.
Afiliação
  • Lee YY; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Park JS; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Leem YH; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Park JE; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Kim DY; Department of Molecular Medicine and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, 808-1 Magok-dong, Gangseo-gu, Seoul, 07804, South Korea.
  • Choi YH; Department of Physiology and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
  • Park EM; Department of Pharmacology and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
  • Kang JL; Department of Brain & Cognitive Sciences, Ewha Womans University, Seoul, South Korea.
  • Kim HS; Department of Physiology and Tissue Injury Defense Research Center, School of Medicine, Ewha Womans University, Seoul, South Korea.
J Neuroinflammation ; 16(1): 246, 2019 Dec 02.
Article em En | MEDLINE | ID: mdl-31791357
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papaverina / Inibidores de Fosfodiesterase / Proteínas Quinases Dependentes de AMP Cíclico / Fármacos Neuroprotetores / Transtornos Parkinsonianos / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Papaverina / Inibidores de Fosfodiesterase / Proteínas Quinases Dependentes de AMP Cíclico / Fármacos Neuroprotetores / Transtornos Parkinsonianos / Anti-Inflamatórios Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article