Genetic Screens to Analyze Pattern Formation of Egg and Embryo in Drosophila: A Personal History.
Annu Rev Genet
; 53: 1-18, 2019 12 03.
Article
em En
| MEDLINE
| ID: mdl-31794267
ABSTRACT
In Drosophila development, the axes of the egg and future embryo are established during oogenesis. To learn about the underlying genetic and molecular pathways that lead to axis formation, I conducted a large-scale genetic screen at the beginning of my independent career. This led to the eventual understanding that both anterior-posterior and dorsal-ventral pattern information is transmitted from the oocyte to the surrounding follicle cells and in turn from the follicle cells back to the oocyte. How I came to conduct this screen and what further insights were gained by studying the mutants isolated in the screen are the topics of this autobiographical article.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Óvulo
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Drosophila melanogaster
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Genética
Limite:
Animals
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article