Thiyl Radical Reactions in the Chemical Degradation of Pharmaceutical Proteins.
Molecules
; 24(23)2019 Nov 28.
Article
em En
| MEDLINE
| ID: mdl-31795282
ABSTRACT
Free radical pathways play a major role in the degradation of protein pharmaceuticals. Inspired by biochemical reactions carried out by thiyl radicals in various enzymatic processes, this review focuses on the role of thiyl radicals in pharmaceutical protein degradation through hydrogen atom transfer, electron transfer, and addition reactions. These processes can lead to the epimerization of amino acids, as well as the formation of various cleavage products and cross-links. Examples are presented for human insulin, human and mouse growth hormone, and monoclonal antibodies.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oxirredução
/
Preparações Farmacêuticas
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Proteínas
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Radicais Livres
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article