Ascorbic acid inhibits the squamous metaplasia that results from treatment of tracheal explants with asbestos or benzo[a]pyrene-coated asbestos.
Cancer Lett
; 42(1-2): 23-8, 1988.
Article
em En
| MEDLINE
| ID: mdl-3180035
ABSTRACT
Hamster tracheal explants were maintained in culture in the presence or absence of benzo[a]pyrene (BP), crocidolite asbestos, or BP-coated crocidolite. Dose-dependent squamous metaplasia was observed in the treated samples. L-Ascorbic acid and DL-alpha-tocopherol were able to partially protect the tracheal explants from the metaplastic response induced by crocidolite. Furthermore, ascorbic acid reduced the extent of metaplasia observed in hamster tracheal explants that were exposed to BP-crocidolite.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amianto
/
Ácido Ascórbico
/
Traqueia
/
Benzo(a)pireno
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article