Triglyceride-lowering effect of the aldose reductase inhibitor cemtirestat-another factor that may contribute to attenuation of symptoms of peripheral neuropathy in STZ-diabetic rats.

Prnova, Marta Soltesova; Kovacikova, Lucia; Svik, Karol; Bezek, Stefan; Elmazoglu, Zübeyir; Karasu, Cimen; Stefek, Milan

Prnova, Marta Soltesova; Kovacikova, Lucia; Svik, Karol; Bezek, Stefan; Elmazoglu, Zübeyir; Karasu, Cimen; Stefek, Milan.

Afiliação

Prnova MS; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia.
Kovacikova L; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia.
Svik K; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia.
Bezek S; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia.
Elmazoglu Z; Department of Medical Pharmacology, Faculty of Medicine, Gazi University, 06510, Besevler, Ankara, Turkey.
Karasu C; Department of Medical Pharmacology, Faculty of Medicine, Gazi University, 06510, Besevler, Ankara, Turkey.
Stefek M; Department of Biochemical Pharmacology, Institute of Experimental Pharmacology and Toxicology, CEM, Slovak Academy of Sciences, Dubravska cesta 9, 841 04, Bratislava, Slovakia. Milan.Stefek@savba.sk.

Naunyn Schmiedebergs Arch Pharmacol ; 393(4): 651-661, 2020 04.

Article em En | MEDLINE | ID: mdl-31802170

Assuntos

Aldeído Redutase/antagonistas & inibidores; Diabetes Mellitus Experimental/tratamento farmacológico; Neuropatias Diabéticas/tratamento farmacológico; Hipoglicemiantes/uso terapêutico; Ácidos Indolacéticos/uso terapêutico; Compostos de Sulfidrila/uso terapêutico; Triglicerídeos/sangue; Animais; Glicemia/efeitos dos fármacos; Diabetes Mellitus Experimental/sangue; Neuropatias Diabéticas/sangue; Hipoglicemiantes/farmacologia; Ácidos Indolacéticos/farmacologia; Masculino; Fragilidade Osmótica/efeitos dos fármacos; Ratos Wistar; Compostos de Sulfidrila/farmacologia

Palavras-chave

Aldose reductase inhibitor; Cemtirestat; Diabetic peripheral neuropathy; Erythrocyte osmotic fragility; STZ-induced diabetic rats; Sorbitol accumulation; Triglycerides

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos de Sulfidrila / Triglicerídeos / Aldeído Redutase / Diabetes Mellitus Experimental / Neuropatias Diabéticas / Hipoglicemiantes / Ácidos Indolacéticos Tipo de estudo: Diagnostic_studies / Prognostic_studies / Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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