FGF9 inhibition by a novel binding peptide has efficacy in gastric and bladder cancer per se and reverses resistance to cisplatin.

Wang, Jizhong; Tan, Xiangpeng; Guo, Qiuxiao; Lin, Xiaomian; Huang, Yishan; Chen, Liankuai; Zeng, Xiangfeng; Li, Rongzhen; Wang, Heng; Wu, Xiaoping

Wang, Jizhong; Tan, Xiangpeng; Guo, Qiuxiao; Lin, Xiaomian; Huang, Yishan; Chen, Liankuai; Zeng, Xiangfeng; Li, Rongzhen; Wang, Heng; Wu, Xiaoping.

Afiliação

Wang J; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Tan X; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China; Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China.
Guo Q; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Lin X; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Huang Y; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Chen L; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Zeng X; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Li R; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Wang H; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China.
Wu X; Institute of Tissue Transplantation and Immunology, Jinan University, Guangzhou 510632, China. Electronic address: twxp@jnu.edu.cn.

Pharmacol Res ; 152: 104575, 2020 02.

Article em En | MEDLINE | ID: mdl-31805343

Assuntos

Fator 9 de Crescimento de Fibroblastos/antagonistas & inibidores; Peptídeos/uso terapêutico; Neoplasias Gástricas/tratamento farmacológico; Neoplasias da Bexiga Urinária/tratamento farmacológico; Animais; Antineoplásicos/farmacologia; Antineoplásicos/uso terapêutico; Linhagem Celular Tumoral; Sobrevivência Celular/efeitos dos fármacos; Cisplatino/farmacologia; Cisplatino/uso terapêutico; Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos; Feminino; Humanos; Camundongos Endogâmicos BALB C; Camundongos Nus; Biblioteca de Peptídeos; Peptídeos/farmacologia; Neoplasias Gástricas/patologia; Carga Tumoral/efeitos dos fármacos; Neoplasias da Bexiga Urinária/patologia

Palavras-chave

Binding peptide; Chemoresistance; Fibroblast growth factor 9 (FGF9); Targeted therapy; Tumor growth

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Peptídeos / Neoplasias Gástricas / Neoplasias da Bexiga Urinária / Fator 9 de Crescimento de Fibroblastos Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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