An energy model for recognizing the prokaryotic promoters based on molecular structure.
Genomics
; 112(2): 2072-2079, 2020 03.
Article
em En
| MEDLINE
| ID: mdl-31809797
ABSTRACT
Promoter is an important functional elements of DNA sequences, which is in charge of gene transcription initiation. Recognizing promoter have important help for understanding the relative life phenomena. Based on the concept that promoter is mainly determined by its sequence and structure, a novel statistical physics model for predicting promoter in Escherichia coli K-12 is proposed. The total energies of DNA local structure of sequence segments in the three benchmark promoter sequence datasets, the sole prediction parameter, are calculated by using principles from statistical physics and information theory. The better results are obtained. And a web-server PhysMPrePro for predicting promoter is established at http//202.207.14.878032/bioinformation/PhysMPrePro/index.asp, so that other scientists can easily get their desired results by our web-server.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Software
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DNA Bacteriano
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Regiões Promotoras Genéticas
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Análise de Sequência de DNA
Tipo de estudo:
Prognostic_studies
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article