Calcium Signaling in ß-cell Physiology and Pathology: A Revisit.
Int J Mol Sci
; 20(24)2019 Dec 04.
Article
em En
| MEDLINE
| ID: mdl-31817135
ABSTRACT
Pancreatic beta (ß) cell dysfunction results in compromised insulin release and, thus, failed regulation of blood glucose levels. This forms the backbone of the development of diabetes mellitus (DM), a disease that affects a significant portion of the global adult population. Physiological calcium (Ca2+) signaling has been found to be vital for the proper insulin-releasing function of ß-cells. Calcium dysregulation events can have a dramatic effect on the proper functioning of the pancreatic ß-cells. The current review discusses the role of calcium signaling in health and disease in pancreatic ß-cells and provides an in-depth look into the potential role of alterations in ß-cell Ca2+ homeostasis and signaling in the development of diabetes and highlights recent work that introduced the current theories on the connection between calcium and the onset of diabetes.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sinalização do Cálcio
/
Células Secretoras de Insulina
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article