The deletion of mutant SOD1 via CRISPR/Cas9/sgRNA prolongs survival in an amyotrophic lateral sclerosis mouse model.

Duan, Weisong; Guo, Moran; Yi, Le; Liu, Yakun; Li, Zhongyao; Ma, Yanqin; Zhang, Guisen; Liu, Yaling; Bu, Hui; Song, Xueqin; Li, Chunyan

Duan, Weisong; Guo, Moran; Yi, Le; Liu, Yakun; Li, Zhongyao; Ma, Yanqin; Zhang, Guisen; Liu, Yaling; Bu, Hui; Song, Xueqin; Li, Chunyan.

Afiliação

Duan W; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, PR China.
Guo M; Neurological Laboratory of Hebei Province, Shijiazhuang, 050000, Hebei, PR China.
Yi L; Institute of Cardiocerebrovascular Disease, Shijiazhuang, 050000, Hebei, PR China.
Liu Y; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, PR China.
Li Z; Neurological Laboratory of Hebei Province, Shijiazhuang, 050000, Hebei, PR China.
Ma Y; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, PR China.
Zhang G; Neurological Laboratory of Hebei Province, Shijiazhuang, 050000, Hebei, PR China.
Liu Y; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, PR China.
Bu H; Neurological Laboratory of Hebei Province, Shijiazhuang, 050000, Hebei, PR China.
Song X; Department of Neurology, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, Hebei, PR China.
Li C; Neurological Laboratory of Hebei Province, Shijiazhuang, 050000, Hebei, PR China.

Gene Ther ; 27(3-4): 157-169, 2020 04.

Article em En | MEDLINE | ID: mdl-31819203

Assuntos

Esclerose Lateral Amiotrófica/terapia; Sistemas CRISPR-Cas; Deleção de Genes; Edição de Genes/métodos; Terapia Genética/métodos; Superóxido Dismutase-1/genética; Esclerose Lateral Amiotrófica/genética; Animais; Feminino; Células HEK293; Humanos; Masculino; Camundongos; Músculo Esquelético/metabolismo; Músculo Esquelético/patologia; Mutação de Sentido Incorreto; RNA Guia de Cinetoplastídeos/genética; RNA Guia de Cinetoplastídeos/metabolismo; Superóxido Dismutase-1/metabolismo

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Terapia Genética / Deleção de Genes / Sistemas CRISPR-Cas / Superóxido Dismutase-1 / Edição de Genes / Esclerose Lateral Amiotrófica Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google