Tumor burden score predicts tumor recurrence of non-functional pancreatic neuroendocrine tumors after curative resection.
HPB (Oxford)
; 22(8): 1149-1157, 2020 08.
Article
em En
| MEDLINE
| ID: mdl-31822386
ABSTRACT
BACKGROUND:
To investigate the feasibility of Tumor Burden Score (TBS) to predict tumor recurrence following curative-intent resection of non-functional pancreatic neuroendocrine tumors (NF-pNETs).METHOD:
The TBS cut-off values were determined by a statistical tool, X-tile. The influence of TBS on recurrence-free survival (RFS) was examined.RESULTS:
Among 842 NF-pNETs patients, there was an incremental worsening of RFS as the TBS increased (5-year RFS, low, medium, and high TBS 92.0%, 73.3%, and 59.3%, respectively; P < 0.001). TBS (AUC 0.74) out-performed both maximum tumor size (AUC 0.65) and number of tumors (AUC 0.5) to predict RFS (TBS vs. maximum tumor size, p = 0.05; TBS vs. number of tumors, p < 0.01). The impact of margin (low TBS R0 80.4% vs. R1 71.9%, p = 0.01 vs. medium TBS R0 55.8% vs. R1 37.5%, p = 0.67 vs. high TBS R0 31.9% vs. R1 12.0%, p = 0.11) and nodal (5-year RFS, low TBS N0 94.9% vs. N1 68.4%, p < 0.01 vs. medium TBS N0 81.8% vs. N1 55.4%, p < 0.01 vs. high TBS N0 58.0% vs. N1 54.2%, p = 0.15) status on 5-year RFS outcomes disappeared among patients who had higher TBS.CONCLUSIONS:
TBS was strongly associated with risk of recurrence and outperformed both tumor size and number alone.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias Pancreáticas
/
Tumores Neuroendócrinos
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article