1,25-(OH)<sub>2</sub>D<sub>3</sub>/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27.

Liu, Dan; Fang, Yu-Xuan; Wu, Xia; Tan, Wei; Zhou, Wei; Zhang, Yu; Liu, Yan-Qing; Li, Guo-Qing

1,25-(OH)₂D₃/Vitamin D receptor alleviates systemic lupus erythematosus by downregulating Skp2 and upregulating p27.

Liu, Dan; Fang, Yu-Xuan; Wu, Xia; Tan, Wei; Zhou, Wei; Zhang, Yu; Liu, Yan-Qing; Li, Guo-Qing.

Afiliação

Liu D; Department of Pathology, Clinical Medical College, Yangzhou University, Yangzhou, 225000, People's Republic of China.
Fang YX; Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hangjiang Road, Yangzhou, Jiangsu Province, 225000, People's Republic of China.
Wu X; Clinical Medical College, Dalian Medical University, Dalian, 116044, People's Republic of China.
Tan W; Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hangjiang Road, Yangzhou, Jiangsu Province, 225000, People's Republic of China.
Zhou W; Clinical Medical College, Dalian Medical University, Dalian, 116044, People's Republic of China.
Zhang Y; Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hangjiang Road, Yangzhou, Jiangsu Province, 225000, People's Republic of China.
Liu YQ; Department of Rheumatology and Immunology, Affiliated Hospital of Yangzhou University, Yangzhou University, No. 368, Hangjiang Road, Yangzhou, Jiangsu Province, 225000, People's Republic of China.
Li GQ; Medical College of Yangzhou University, Yangzhou, 225000, People's Republic of China.

Cell Commun Signal ; 17(1): 163, 2019 12 10.

Article em En | MEDLINE | ID: mdl-31823770

Assuntos

Calcitriol/metabolismo; Inibidor de Quinase Dependente de Ciclina p27/metabolismo; Lúpus Eritematoso Sistêmico/metabolismo; Receptores de Calcitriol/metabolismo; Proteínas Quinases Associadas a Fase S/metabolismo; Adolescente; Adulto; Idoso; Animais; Calcitriol/administração & dosagem; Calcitriol/análise; Criança; Inibidor de Quinase Dependente de Ciclina p27/análise; Suplementos Nutricionais; Regulação para Baixo; Feminino; Humanos; Lúpus Eritematoso Sistêmico/diagnóstico; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Camundongos Knockout; Pessoa de Meia-Idade; Receptores de Calcitriol/análise; Receptores de Calcitriol/deficiência; Proteínas Quinases Associadas a Fase S/análise; Transdução de Sinais; Regulação para Cima; Adulto Jovem

Palavras-chave

1,25(oh)2D3; Inflammatory factors; Renal injury; Skp2; Systemic lupus erythematosus; Vitamin D receptor; p27

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Calcitriol / Receptores de Calcitriol / Proteínas Quinases Associadas a Fase S / Inibidor de Quinase Dependente de Ciclina p27 / Lúpus Eritematoso Sistêmico Tipo de estudo: Diagnostic_studies Limite: Adolescent / Adult / Aged / Animals / Child / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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