Synthesis and biological evaluation of novel pyrazolo[1,5-a]pyrimidines: Discovery of a selective inhibitor of JAK1 JH2 pseudokinase and VPS34.

Singleton, Justin D; Dass, Reuben; Neubert, Nathaniel R; Smith, Rachel M; Webber, Zak; Hansen, Marc D H; Peterson, Matt A

Singleton, Justin D; Dass, Reuben; Neubert, Nathaniel R; Smith, Rachel M; Webber, Zak; Hansen, Marc D H; Peterson, Matt A.

Afiliação

Singleton JD; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.
Dass R; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA.
Neubert NR; Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA.
Smith RM; Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA.
Webber Z; Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA.
Hansen MDH; Department of Physiology & Developmental Biology, Brigham Young University, Provo, UT 84602, USA.
Peterson MA; Department of Chemistry and Biochemistry, Brigham Young University, Provo, UT 84602, USA. Electronic address: matt_peterson@byu.edu.

Bioorg Med Chem Lett ; 30(2): 126813, 2020 01 15.

Article em En | MEDLINE | ID: mdl-31831383

Assuntos

Classe III de Fosfatidilinositol 3-Quinases/antagonistas & inibidores; Janus Quinase 1/antagonistas & inibidores; Pirimidinas/síntese química; Humanos; Estrutura Molecular; Relação Estrutura-Atividade

Palavras-chave

JAK1 JH2 pseudokinase inhibitor; Microwave assisted synthesis; Pyrazolo[1,5-a]pyrimidines; VPS34 kinase inhibitor

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Pirimidinas / Janus Quinase 1 / Classe III de Fosfatidilinositol 3-Quinases Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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