Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on <i>Plasmodium falciparum</i> Glutathione Reductase.

Maroziene, Audrone; Lesanavicius, Mindaugas; Davioud-Charvet, Elisabeth; Aliverti, Alessandro; Grellier, Philippe; Sarlauskas, Jonas; Cenas, Narimantas

Antiplasmodial Activity of Nitroaromatic Compounds: Correlation with Their Reduction Potential and Inhibitory Action on Plasmodium falciparum Glutathione Reductase.

Maroziene, Audrone; Lesanavicius, Mindaugas; Davioud-Charvet, Elisabeth; Aliverti, Alessandro; Grellier, Philippe; Sarlauskas, Jonas; Cenas, Narimantas.

Afiliação

Maroziene A; Department of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.
Lesanavicius M; Department of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.
Davioud-Charvet E; UMR7042 CNRS-Unistra-UHA, Laboratoire d'Innovation Moléculaire et Applications (LIMA), Bioorganic and Medicinal Chemistry Team, European School of Chemistry, Polymers and Materials, 25 rue Becquerel, F-67087 Strasbourg, France.
Aliverti A; Department of Biosciences, Universita degli Studi di Milano, via Celoria 26, I-20133 Milano, Italy.
Grellier P; MCAM, UMR7245, Museum National d'Histoire Naturelle, CNRS, 61 rue Buffon, F-75231 Paris CEDEX 05, France.
Sarlauskas J; Department of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.
Cenas N; Department of Xenobiotics Biochemistry, Institute of Biochemistry of Vilnius University, Sauletekio 7, LT-10257 Vilnius, Lithuania.

Molecules ; 24(24)2019 Dec 10.

Article em En | MEDLINE | ID: mdl-31835450

Assuntos

Antimaláricos/química; Antimaláricos/farmacologia; Glutationa Redutase/antagonistas & inibidores; Oxirredução/efeitos dos fármacos; Plasmodium falciparum/efeitos dos fármacos; Plasmodium falciparum/enzimologia; Antioxidantes/química; Antioxidantes/farmacologia; Relação Dose-Resposta a Droga; Inibidores Enzimáticos/química; Inibidores Enzimáticos/farmacologia; Eritrócitos/efeitos dos fármacos; Eritrócitos/metabolismo; Eritrócitos/parasitologia; Ferredoxina-NADP Redutase/metabolismo; Humanos; Concentração Inibidora 50; Estrutura Molecular; NADP/metabolismo

Palavras-chave

Plasmodium falciparum; enzyme inhibition; ferredoxin:NADP+ oxidoreductase; glutathione reductase; nitroaromatics

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oxirredução / Plasmodium falciparum / Glutationa Redutase / Antimaláricos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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