Synthesis and structure-activity relationships of novel abietane diterpenoids with activity against <i>Staphylococcus aureus</i>.

Chabán, Macarena Funes; I Antoniou, Antonia; Karagianni, Catherine; Toumpa, Dimitra; Joray, Mariana Belén; Bocco, José Luis; Sola, Claudia; M Athanassopoulos, Constantinos; Carpinella, María Cecilia

Synthesis and structure-activity relationships of novel abietane diterpenoids with activity against Staphylococcus aureus.

Chabán, Macarena Funes; I Antoniou, Antonia; Karagianni, Catherine; Toumpa, Dimitra; Joray, Mariana Belén; Bocco, José Luis; Sola, Claudia; M Athanassopoulos, Constantinos; Carpinella, María Cecilia.

Afiliação

Chabán MF; Research Institute of Natural Resources & Sustainability José Sánchez Labrador S.J. (IRNASUS-CONICET), School of Chemistry, Catholic University of Córdoba, Córdoba, Argentina.
I Antoniou A; Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, Patras, Greece.
Karagianni C; Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, Patras, Greece.
Toumpa D; Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, Patras, Greece.
Joray MB; Research Institute of Natural Resources & Sustainability José Sánchez Labrador S.J. (IRNASUS-CONICET), School of Chemistry, Catholic University of Córdoba, Córdoba, Argentina.
Bocco JL; CIBICI-CONICET & Department of Clinical Biochemistry, Faculty of Chemical Science, National University of Córdoba, Córdoba, Argentina.
Sola C; CIBICI-CONICET & Department of Clinical Biochemistry, Faculty of Chemical Science, National University of Córdoba, Córdoba, Argentina.
M Athanassopoulos C; Synthetic Organic Chemistry Laboratory, Department of Chemistry, University of Patras, Patras, Greece.
Carpinella MC; Research Institute of Natural Resources & Sustainability José Sánchez Labrador S.J. (IRNASUS-CONICET), School of Chemistry, Catholic University of Córdoba, Córdoba, Argentina.

Future Med Chem ; 11(24): 3109-3124, 2019 12.

Article em En | MEDLINE | ID: mdl-31838897

Assuntos

Abietanos/síntese química; Antibacterianos/síntese química; Staphylococcus aureus Resistente à Meticilina/efeitos dos fármacos; Abietanos/química; Abietanos/farmacologia; Abietanos/toxicidade; Antibacterianos/química; Antibacterianos/farmacologia; Antibacterianos/toxicidade; Sobrevivência Celular/efeitos dos fármacos; Células Cultivadas; Aberrações Cromossômicas/induzido quimicamente; Eritrócitos/efeitos dos fármacos; Hemólise/efeitos dos fármacos; Humanos; Leucócitos Mononucleares/efeitos dos fármacos; Testes de Sensibilidade Microbiana; Estrutura Molecular; Cebolas/efeitos dos fármacos; Cebolas/genética; Relação Estrutura-Atividade

Palavras-chave

antibacterial activity; dehydroabietic acid derivatives; methicillin-resistant Staphylococcus aureus; methicillin-susceptible Staphylococcus aureus; structure−activity relationships

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Abietanos / Staphylococcus aureus Resistente à Meticilina / Antibacterianos Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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