H<sub>2</sub>S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.

Zhou, Yueyuan; Zhu, Xiaoyan; Wang, Xuan; Peng, Yi; Du, Jiankui; Yin, Hongling; Yang, Hui; Ni, Xin; Zhang, Weiru

H₂S alleviates renal injury and fibrosis in response to unilateral ureteral obstruction by regulating macrophage infiltration via inhibition of NLRP3 signaling.

Zhou, Yueyuan; Zhu, Xiaoyan; Wang, Xuan; Peng, Yi; Du, Jiankui; Yin, Hongling; Yang, Hui; Ni, Xin; Zhang, Weiru.

Afiliação

Zhou Y; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Zhu X; Department of Physiology, Second Military Medical University, Shanghai, China.
Wang X; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Peng Y; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Du J; National International Joint Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, Second Military Medical University, Shanghai, China.
Yin H; Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Yang H; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China.
Ni X; National International Joint Research Center for Medical Metabolomics, Xiangya Hospital, Central South University, Changsha, Hunan, China; Department of Physiology, Second Military Medical University, Shanghai, China. Electronic address: xinni2018@csu.edu.cn.
Zhang W; Department of Rheumatology and Immunology, Xiangya Hospital, Central South University, Changsha, Hunan, China. Electronic address: zhangwr@csu.edu.cn.

Exp Cell Res ; 387(1): 111779, 2020 02 01.

Article em En | MEDLINE | ID: mdl-31846625

Assuntos

Injúria Renal Aguda/tratamento farmacológico; Fibrose/tratamento farmacológico; Sulfeto de Hidrogênio/farmacologia; Macrófagos/efeitos dos fármacos; Proteína 3 que Contém Domínio de Pirina da Família NLR/metabolismo; Transdução de Sinais/efeitos dos fármacos; Obstrução Ureteral/tratamento farmacológico; Injúria Renal Aguda/metabolismo; Animais; Fibrose/metabolismo; Inflamassomos/efeitos dos fármacos; Inflamassomos/metabolismo; Inflamação/tratamento farmacológico; Inflamação/metabolismo; Rim/efeitos dos fármacos; Rim/metabolismo; Macrófagos/metabolismo; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Insuficiência Renal Crônica/tratamento farmacológico; Insuficiência Renal Crônica/metabolismo; Obstrução Ureteral/metabolismo

Palavras-chave

Hydrogen sulfide; Macrophage infiltration; NLRP3 inflammasome; Renal injury; Renal interstitial fibrosis; Unilateral ureteral obstruction

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Obstrução Ureteral / Fibrose / Transdução de Sinais / Injúria Renal Aguda / Proteína 3 que Contém Domínio de Pirina da Família NLR / Sulfeto de Hidrogênio / Macrófagos Limite: Animals Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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