[Spinal Muscular Atrophy - expert recommendations for the use of nusinersen in adult patients]. / Spinale Muskelatrophie Expertenempfehlungen zur Behandlung von erwachsenen Patienten mit Nusinersen.
Fortschr Neurol Psychiatr
; 87(12): 703-710, 2019 Dec.
Article
em De
| MEDLINE
| ID: mdl-31847032
ABSTRACT
With Nusinersen, a first causative treatment for 5q-associated spinal muscular atrophy (SMA) has been available in Europe since 2017. Real-world data from neuromuscular clinical centers in Germany increasingly show a therapeutic benefit of nusinersen also in adult SMA patients of both sexes in many cases, relevant improvements in or at least a stabilization of motor functions are achieved, potentially leading to enhanced autonomy in activities of daily life and to improved quality of living. Even in patients with severe spinal deformities, intrathecal application is usually feasible and safe using imaging modalities. Regular systematic evaluation of the motor status with validated instruments is crucial for adequate monitoring of the therapeutic effects. The documentation in SMA registries enables systematic development of a database for further development of this novel treatment paradigm. Relevant aspects of this novel therapeutic principle were discussed at an experts conference in Frankfurtâ/âMain in February 2019.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligonucleotídeos
/
Atrofia Muscular Espinal
Limite:
Adult
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
De
Ano de publicação:
2019
Tipo de documento:
Article