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Comparative iTRAQ Proteomics Reveals Multiple Effects of Selenium Yeast on Dairy Cows in Parturition.
Ren, Zhi-Hua; Bai, Li-Peng; Shen, Liu-Hong; Luo, Zheng-Zhong; Zhou, Zi-Han; Zuo, Zhi-Cai; Ma, Xiao-Ping; Deng, Jun-Liang; Wang, Ya; Xu, Sheng-Yu; Luo, Yu-Heng; Cao, Sui-Zhong; Yu, Shu-Min.
Afiliação
  • Ren ZH; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Bai LP; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Shen LH; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Luo ZZ; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Zhou ZH; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Zuo ZC; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Ma XP; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Deng JL; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Wang Y; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Xu SY; Animal Nutrition Institute, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Luo YH; Animal Nutrition Institute, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Cao SZ; Key Laboratory of Animal Disease-resistant Nutrition, Ministry of Education; Key Laboratory of Animal Disease-resistant Nutrition and Feed, Ministry of Agriculture and Rural Affairs; Animal Nutrition Institute, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
  • Yu SM; Key Laboratory of Animal Disease and Human Health of Sichuan Province, College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang District, Chengdu, 611130, China.
Biol Trace Elem Res ; 197(2): 464-474, 2020 Oct.
Article em En | MEDLINE | ID: mdl-31858401
The effects of prepartum dietary supplementation with selenium yeast on low abundant plasma proteins in postpartum dairy cows are not known. In this study, 24 healthy parturient dairy cows were divided into two groups (group C, a control group, and group T, a selenium treatment group). Low abundance proteins were extracted from plasma samples of calving cows, and 542 proteins were identified by isobaric tags for relative and absolute quantitation (iTRAQ) proteomic analysis. Dietary supplementation with selenium yeast caused differential abundance of 48 proteins with a fold change of more than 1.2 or less than 0.83 (p < 0.05); 14 proteins were upregulated and 34 were downregulated. The top five gene ontology (GO) enrichment terms for the differentially expressed proteins were protein homotetramerization (or tetramerization), defense response to bacteria or fungus, acute-phase reactions, nucleotide catabolic process, and positive regulation of lipid metabolic process. All proteins involved in acute-phase reactions were downregulated, indicating that selenium ameliorates systemic inflammation. The vast majority of proteins involved in the defense response to microorganisms were downregulated, thereby affecting innate immunity. The decreased abundance of apolipoprotein A-I and apolipoprotein C-II, critical proteins for positive regulation of lipid metabolism, indicated that selenium may optimize lipid metabolism. The iTRAQ results showed that prenatal supplementation with yeast selenium can relieve systemic inflammation after parturition. Moreover, selenium may reduce the effects of metabolic diseases, which can improve glyconeogenesis and prevent ketosis and fatty liver.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selênio Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Selênio Limite: Animals / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2020 Tipo de documento: Article