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Prevention of Acute Upper Respiratory Infections by Consumption of Catechins in Healthcare Workers: A Randomized, Placebo-Controlled Trial.
Furushima, Daisuke; Nishimura, Takuma; Takuma, Norikata; Iketani, Ryo; Mizuno, Tomohito; Matsui, Yuji; Yamaguchi, Tohru; Nakashima, Yu; Yamamoto, Shinji; Hibi, Masanobu; Yamada, Hiroshi.
Afiliação
  • Furushima D; Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
  • Nishimura T; Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
  • Takuma N; White Cross Nursing Home, Tokyo 189-0021, Japan.
  • Iketani R; Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
  • Mizuno T; Biological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
  • Matsui Y; Biological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
  • Yamaguchi T; Health Care Food Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
  • Nakashima Y; Personal Healthcare Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
  • Yamamoto S; Personal Healthcare Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
  • Hibi M; Biological Science Research Laboratories, Kao Corporation, Tokyo 131-8501, Japan.
  • Yamada H; Department of Drug Evaluation and Informatics, Graduate School of Pharmaceutical Sciences, University of Shizuoka, Shizuoka 422-8526, Japan.
Nutrients ; 12(1)2019 Dec 18.
Article em En | MEDLINE | ID: mdl-31861349
Catechins, phytochemicals contained mainly in green tea, exhibit antiviral activity against various acute infectious diseases experimentally. Clinical evidence supporting these effects, however, is not conclusive. We performed a placebo-controlled, single-blind, randomized control trial to evaluate the clinical effectiveness of consumption of catechins-containing beverage for preventing acute upper respiratory tract infections (URTIs). Two hundred and seventy healthcare workers were randomly allocated to high-catechin (three daily doses of 57 mg catechins and 100 mg xanthan gum), low-catechin (one daily dose of 57 mg catechins and 100 mg xanthan gum), or placebo (0 mg catechins and 100 mg xanthan gum) group. Subjects consumed a beverage with or without catechins for 12 weeks from December 2017 through February 2018. The primary endpoint was incidence of URTIs compared among groups using a time-to-event analysis. A total of 255 subjects were analyzed (placebo group n = 86, low-catechin group n = 85, high catechin group n = 84). The URTI incidence rate was 26.7% in the placebo group, 28.2% in the low-catechin group, and 13.1% in the high-catechin group (log rank test, p = 0.042). The hazard ratio (95% confidence interval (CI)) with reference to the placebo group was 1.09 (0.61-1.92) in the low-catechin group and 0.46 (0.23-0.95) in the high-catechin group. These findings suggest that catechins combined with xanthan gum protect against URTIs.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Chá / Catecóis / Pessoal de Saúde Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Respiratórias / Chá / Catecóis / Pessoal de Saúde Tipo de estudo: Clinical_trials Limite: Adult / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2019 Tipo de documento: Article