Hierarchical Self-Assembly of Poly-Pseudorotaxanes into Artificial Microtubules.
Angew Chem Int Ed Engl
; 59(9): 3460-3464, 2020 02 24.
Article
em En
| MEDLINE
| ID: mdl-31863556
ABSTRACT
Hierarchical self-assembly of building blocks over multiple length scales is ubiquitous in living organisms. Microtubules are one of the principal cellular components formed by hierarchical self-assembly of nanometer-sized tubulin heterodimers into protofilaments, which then associate to form micron-length-scale, multi-stranded tubes. This peculiar biological process is now mimicked with a fully synthetic molecule, which forms a 11 host-guest complex with cucurbit[7]uril as a globular building block, and then polymerizes into linear poly-pseudorotaxanes that associate laterally with each other in a self-shape-complementary manner to form a tubular structure with a length over tens of micrometers. Molecular dynamic simulations suggest that the tubular assembly consists of eight poly-pseudorotaxanes that wind together to form a 4.5â
nm wide multi-stranded tubule.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Microtúbulos
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article