Preferential Neurodegeneration in the Dentate Gyrus by Amyloid ß<sub>1-42</sub>-Induced Intracellular Zn<sup>2+</sup>Dysregulation and Its Defense Strategy.

Tamano, Haruna; Takiguchi, Mako; Tanaka, Yukino; Murakami, Taku; Adlard, Paul A; Bush, Ashley I; Takeda, Atsushi

Preferential Neurodegeneration in the Dentate Gyrus by Amyloid ß_1-42-Induced Intracellular Zn²⁺Dysregulation and Its Defense Strategy.

Tamano, Haruna; Takiguchi, Mako; Tanaka, Yukino; Murakami, Taku; Adlard, Paul A; Bush, Ashley I; Takeda, Atsushi.

Afiliação

Tamano H; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Takiguchi M; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Tanaka Y; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Murakami T; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan.
Adlard PA; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Bush AI; The Florey Institute of Neuroscience and Mental Health, The University of Melbourne, Parkville, VIC, 3052, Australia.
Takeda A; Department of Neurophysiology, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, Suruga-ku, Shizuoka, 422-8526, Japan. takedaa@u-shizuoka-ken.ac.jp.

Mol Neurobiol ; 57(4): 1875-1888, 2020 Apr.

Article em En | MEDLINE | ID: mdl-31865526

Assuntos

Peptídeos beta-Amiloides/toxicidade; Giro Denteado/patologia; Espaço Intracelular/metabolismo; Degeneração Neural/patologia; Zinco/metabolismo; Animais; Disfunção Cognitiva/tratamento farmacológico; Giro Denteado/efeitos dos fármacos; Dexametasona/farmacologia; Dexametasona/uso terapêutico; Humanos; Injeções Intraventriculares; Masculino; Camundongos

Palavras-chave

Alzheimer's disease; Amyloid ß142; Dentate gyrus; Extracellular Zn2 +; Metallothionein; Neurodegeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Zinco / Peptídeos beta-Amiloides / Giro Denteado / Espaço Intracelular / Degeneração Neural Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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