RSAT variation-tools: An accessible and flexible framework to predict the impact of regulatory variants on transcription factor binding.

Santana-Garcia, Walter; Rocha-Acevedo, Maria; Ramirez-Navarro, Lucia; Mbouamboua, Yvon; Thieffry, Denis; Thomas-Chollier, Morgane; Contreras-Moreira, Bruno; van Helden, Jacques; Medina-Rivera, Alejandra

Santana-Garcia, Walter; Rocha-Acevedo, Maria; Ramirez-Navarro, Lucia; Mbouamboua, Yvon; Thieffry, Denis; Thomas-Chollier, Morgane; Contreras-Moreira, Bruno; van Helden, Jacques; Medina-Rivera, Alejandra.

Afiliação

Santana-Garcia W; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
Rocha-Acevedo M; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro 76230, Mexico.
Ramirez-Navarro L; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro 76230, Mexico.
Mbouamboua Y; Laboratorio Internacional de Investigación sobre el Genoma Humano, Universidad Nacional Autónoma de México, Campus Juriquilla, Blvd Juriquilla 3001, Santiago de Querétaro 76230, Mexico.
Thieffry D; Fondation Congolaise pour la Recherche Médicale, Brazzaville, People's Republic of Congo.
Thomas-Chollier M; Aix-Marseille Univ, INSERM UMR S 1090, Theory and Approaches of Genome Complexity (TAGC), F-13288 Marseille, France.
Contreras-Moreira B; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
van Helden J; Institut de Biologie de l'ENS (IBENS), Département de biologie, École normale supérieure, CNRS, INSERM, Université PSL, 75005 Paris, France.
Medina-Rivera A; Estación Experimental de Aula Dei-CSIC, Zaragoza, Spain.

Comput Struct Biotechnol J ; 17: 1415-1428, 2019.

Article em En | MEDLINE | ID: mdl-31871587

Palavras-chave

Binding motifs; CEU, Northern Europeans from Utah; CRM, Cis-Regulatory Module; GWAS, Genome Wide Association Studies; LD, Linkage Disequilibrium; MPRA, Massively Parallel Reporter Assays: MPRA; PSSM, Position Specific Scoring Matrix; Position specific scoring matrix; ROC, Receiver Operating Characteristic; RSAT, Regulatory Sequence Analysis Tools; Regulatory variants; SNP, Single Nucleotide Polymorphism; SNPs; SOIs, SNPs of Interest; TF, Transcription Factor; TFBS, Transcription Factor Binding Site; Transcription factors; eQTL, Expression Quantitative Trait Loci; rsID, Reference SNP Identifier

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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