Spermidine protects from age-related synaptic alterations at hippocampal mossy fiber-CA3 synapses.
Sci Rep
; 9(1): 19616, 2019 12 23.
Article
em En
| MEDLINE
| ID: mdl-31873156
ABSTRACT
Aging is associated with functional alterations of synapses thought to contribute to age-dependent memory impairment (AMI). While therapeutic avenues to protect from AMI are largely elusive, supplementation of spermidine, a polyamine normally declining with age, has been shown to restore defective proteostasis and to protect from AMI in Drosophila. Here we demonstrate that dietary spermidine protects from age-related synaptic alterations at hippocampal mossy fiber (MF)-CA3 synapses and prevents the aging-induced loss of neuronal mitochondria. Dietary spermidine rescued age-dependent decreases in synaptic vesicle density and largely restored defective presynaptic MF-CA3 long-term potentiation (LTP) at MF-CA3 synapses (MF-CA3) in aged animals. In contrast, spermidine failed to protect CA3-CA1 hippocampal synapses characterized by postsynaptic LTP from age-related changes in function and morphology. Our data demonstrate that dietary spermidine attenuates age-associated deterioration of MF-CA3 synaptic transmission and plasticity. These findings provide a physiological and molecular basis for the future therapeutic usage of spermidine.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vesículas Sinápticas
/
Envelhecimento
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Espermidina
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Potenciação de Longa Duração
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Transmissão Sináptica
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Fibras Musgosas Hipocampais
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Região CA3 Hipocampal
Limite:
Animals
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article