Construction of Ribonuclease-Decorated Artificial Virus-like Capsid by Peptide Self-assembly.
J Org Chem
; 85(3): 1668-1673, 2020 02 07.
Article
em En
| MEDLINE
| ID: mdl-31875395
ABSTRACT
Artificial virus-like capsids decorated with ribonuclease S (RNase S) on their exterior were constructed by the self-assembly of ß-annulus-S-peptide and the interaction between S-peptide moiety and S-protein. The ß-annulus-S-peptide was synthesized by native chemical ligation of ß-annulus-SBz peptide with Cys-containing S-peptide that self-assembled into artificial virus-like capsids of approximately 47 nm in size. Reconstruction of RNase S on the artificial virus-like capsids afforded spherical assembly attached small spheres on the surface, which retained ribonuclease activity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Capsídeo
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article