AlleleProfileR: A versatile tool to identify and profile sequence variants in edited genomes.
PLoS One
; 14(12): e0226694, 2019.
Article
em En
| MEDLINE
| ID: mdl-31877162
ABSTRACT
Gene editing strategies, such as zinc-finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and clustered regularly interspaced short palindromic repeat/Cas9 (CRISPR/Cas9), are revolutionizing biology. However, quantitative and sensitive detection of targeted mutations are required to evaluate and quantify the genome editing outcomes. Here we present AlleleProfileR, a new analysis tool, written in a combination of R and C++, with the ability to batch process the sequence analysis of large and complex genome editing experiments, including the recently developed base editing technologies.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Edição de Genes
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article