A hirudin catching ELISA for quantitating the anticoagulant in biological fluids.
Thromb Res
; 51(6): 617-25, 1988 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-3187968
ABSTRACT
A catching ELISA has been developed that permits a quantitation of the anticoagulant hirudin in buffer, urine and plasma. In plasma hirudin can be determined in concentrations ranging from 0.2 to 25 ng/ml (2.4 X 10(-3) to 0.3 AT-U/ml), in urine between 0.8 and 200 ng/ml (0.01 and 2.4 AT-U/ml). The enzyme immunoassay allows a rapid, sensitive and reproducible quantitation of hirudin, and can thus be used to assess the pharmacokinetics of the anticoagulant in patients after parenteral and/or topic administration.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hirudinas
Limite:
Animals
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article