Systematic Optimization, In Vitro Drug Release, and Preliminary Nonclinical Toxicity Assessment of Nonphospholipid-Based Topical Ophthalmic Emulsions Containing 0.05 or 0.1% w/w Cyclosporin A for Dry-Eye Syndrome Management.

Rahman, Syed Nazrin Ruhina; Pawde, Datta Maroti; Katari, Oly; Hmingthansanga, Victor; Shunmugaperumal, Tamilvanan

Rahman, Syed Nazrin Ruhina; Pawde, Datta Maroti; Katari, Oly; Hmingthansanga, Victor; Shunmugaperumal, Tamilvanan.

Afiliação

Rahman SNR; National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, C/O NETES Institute of Technology & Science, NH-37, Santipur, Parli Part, Mirza, Guwahati, Assam, 781125, India.
Pawde DM; National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, C/O NETES Institute of Technology & Science, NH-37, Santipur, Parli Part, Mirza, Guwahati, Assam, 781125, India.
Katari O; National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, C/O NETES Institute of Technology & Science, NH-37, Santipur, Parli Part, Mirza, Guwahati, Assam, 781125, India.
Hmingthansanga V; National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, C/O NETES Institute of Technology & Science, NH-37, Santipur, Parli Part, Mirza, Guwahati, Assam, 781125, India.
Shunmugaperumal T; National Institute of Pharmaceutical Education and Research (NIPER)-Guwahati, C/O NETES Institute of Technology & Science, NH-37, Santipur, Parli Part, Mirza, Guwahati, Assam, 781125, India. tamilvanan1@yahoo.co.in.

AAPS PharmSciTech ; 21(2): 36, 2019 Dec 26.

Article em En | MEDLINE | ID: mdl-31879832

Assuntos

Inibidores de Calcineurina/administração & dosagem; Ciclosporina/administração & dosagem; Liberação Controlada de Fármacos; Síndromes do Olho Seco/tratamento farmacológico; Administração Oftálmica; Inibidores de Calcineurina/toxicidade; Ciclosporina/toxicidade; Emulsões; Humanos; Técnicas In Vitro; Tamanho da Partícula

Palavras-chave

Taguchi design; cyclosporin A; face-centered central composite design (CCD); failure mode effect analysis (FEMA); risk priority number (RPN); topical ophthalmic emulsion

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Síndromes do Olho Seco / Ciclosporina / Inibidores de Calcineurina / Liberação Controlada de Fármacos Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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