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New activators of eIF2α Kinase Heme-Regulated Inhibitor (HRI) with improved biophysical properties.
Zhang, Qingwen; Du, Ronghui; Reis Monteiro Dos Santos, Guilherme Rodrigo; Yefidoff-Freedman, Revital; Bohm, Andrew; Halperin, Jose; Chorev, Michael; Aktas, Bertal H.
Afiliação
  • Zhang Q; Division of Medicinal and Process Chemistry, Shanghai Institute of Pharmaceutical Industry, Pudong, Shanghai, 201203, China; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Du R; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA; Medicine School of Nanjing University, Nanjing, Jiangsu, 210093, China.
  • Reis Monteiro Dos Santos GR; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Yefidoff-Freedman R; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Bohm A; Tufts University Medical School, Boston, MA, 02117, USA.
  • Halperin J; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Chorev M; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA.
  • Aktas BH; Hematology Laboratory for Translational Research, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02115, USA. Electronic address: huseyin_aktas@hms.harvard.edu.
Eur J Med Chem ; 187: 111973, 2020 Feb 01.
Article em En | MEDLINE | ID: mdl-31881453
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ureia / Fator de Iniciação 2 em Eucariotos / Heme / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ureia / Fator de Iniciação 2 em Eucariotos / Heme / Antineoplásicos Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article