Reshaping Chromatin Architecture around DNA Breaks.

Caron, Pierre; Polo, Sophie E

Caron, Pierre; Polo, Sophie E.

Afiliação

Caron P; Epigenetics and Cell Fate Centre, UMR7216 CNRS, Université de Paris, F-75013, Paris, France.
Polo SE; Epigenetics and Cell Fate Centre, UMR7216 CNRS, Université de Paris, F-75013, Paris, France. Electronic address: sophie.polo@univ-paris-diderot.fr.

Trends Biochem Sci ; 45(3): 177-179, 2020 03.

Article em En | MEDLINE | ID: mdl-31882194

ABSTRACT

ABSTRACT

DNA double-strand breaks (DSBs) elicit major chromatin changes. Using super-resolution microscopy in human cells, Ochs et al. unveil that the DSB response protein 53BP1 and its effector RIF1 organize DSB-flanking chromatin into circular micro-domains. These structures control the spatial distribution of DSB repair factors safeguarding genome integrity.

Assuntos

Cromatina; Reparo do DNA; Quebras de DNA de Cadeia Dupla; Humanos

Palavras-chave

53BP1; DNA double-strand break repair; RIF1; chromatin topology; cohesins; super-resolution microscopy

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Cromatina / Reparo do DNA Limite: Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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