Positioning Heterochromatin at the Nuclear Periphery Suppresses Histone Turnover to Promote Epigenetic Inheritance.

Holla, Sahana; Dhakshnamoorthy, Jothy; Folco, H Diego; Balachandran, Vanivilasini; Xiao, Hua; Sun, Ling-Ling; Wheeler, David; Zofall, Martin; Grewal, Shiv I S

Holla, Sahana; Dhakshnamoorthy, Jothy; Folco, H Diego; Balachandran, Vanivilasini; Xiao, Hua; Sun, Ling-Ling; Wheeler, David; Zofall, Martin; Grewal, Shiv I S.

Afiliação

Holla S; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Dhakshnamoorthy J; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Folco HD; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Balachandran V; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Xiao H; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Sun LL; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Wheeler D; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Zofall M; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA.
Grewal SIS; Laboratory of Biochemistry and Molecular Biology, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA. Electronic address: grewals@mail.nih.gov.

Cell ; 180(1): 150-164.e15, 2020 01 09.

Article em En | MEDLINE | ID: mdl-31883795

Assuntos

Epigênese Genética/genética; Heterocromatina/genética; Heterocromatina/metabolismo; Proteínas de Ciclo Celular/metabolismo; Núcleo Celular/metabolismo; Proteínas Cromossômicas não Histona/metabolismo; Repressão Epigenética/genética; Inativação Gênica; Hereditariedade; Histonas/genética; Histonas/metabolismo; Metilação; Proteínas Nucleares/metabolismo; Schizosaccharomyces/genética; Schizosaccharomyces/metabolismo; Proteínas de Schizosaccharomyces pombe/genética; Proteínas de Schizosaccharomyces pombe/metabolismo

Palavras-chave

chromatin; epigenetic inheritance; gene regulation; heterochromatin; heterochromatin spreading; histone methylation; nuclear organization; nuclear periphery

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Heterocromatina / Epigênese Genética Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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