Drug-Related Problems Increase Healthcare Costs for People Living with Dementia.
J Alzheimers Dis
; 73(2): 791-799, 2020.
Article
em En
| MEDLINE
| ID: mdl-31884468
ABSTRACT
BACKGROUND:
Drug-related problems (DRP) are common in the elderly population, especially in people living with dementia (PwD). DRP are associated with adverse outcomes that could result in increased costs.OBJECTIVE:
The objective of the study was to analyze the association between DRP and healthcare costs in PwD.METHODS:
The analysis was based on the cross-sectional data of 424 PwD. Compliance, adverse effects, and drug administration of prescribed and over-the-counter drugs taken were assessed. DRP were identified and classified by pharmacists using an adapted German version of "PIE-Doc®". Healthcare utilization was assessed retrospectively used to calculated costs from a public payer perspective using standardized unit costs. The associations between DRP and healthcare costs were analyzed using multiple linear regression models.RESULTS:
394 PwD (93%) had at least one DRP. An inappropriate drug choice was significantly associated with increased total costs (bâ=â2,718; CI95% 1,448-3,988) due to significantly higher costs for hospitalization (bâ=â1,936; 670-3,202) and for medications (bâ=â417; 68-765). Problems with medication dosage and drug interactions were significantly associated with higher medication costs (bâ=â679; 31-1,328; and bâ=â630; 259-1,001, respectively).CONCLUSIONS:
DRP could significantly lead to adverse outcomes for PwD and healthcare payers, reflected by a higher hospitalization and costs, respectively. Further research is needed to clarify on interventions and approaches efficiently avoiding DRP and on the effect on patient-reported and economic outcomes.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Custos de Cuidados de Saúde
/
Demência
/
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos
Tipo de estudo:
Health_economic_evaluation
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Aged80
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article