Antimicrobial Secondary Metabolites from the Seawater-Derived Fungus Aspergillus sydowii SW9.
Molecules
; 24(24)2019 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-31888157
ABSTRACT
Marine-derived fungi are considered to be valuable producers of bioactive secondary metabolites used as lead compounds with medicinal importance. In this study, chemical investigation of the seawater-derived fungus Aspergillus sydowii SW9 led to the isolation and identification of one new quinazolinone alkaloid, 2-(4-hydroxybenzyl)-4-(3-acetyl)quinazolin-one (1), one new aromatic bisabolene-type sesquiterpenoid, (2) and one new chorismic acid analogue (3), as well as two known alkaloids (compounds 4 and 5). Their structures were determined by extensive 1D/2D NMR and mass spectrometric data, and the absolute configurations of 2 and 3 were assigned by the analysis of ECD spectra aided by quantum chemical computations. Compounds 1, 2, and 4 exhibited selective inhibitory activities against the human pathogenic bacteria Escherichia coli, Staphylococcus aureus, S. epidermidis, and Streptococcus pneumoniae, with MIC values ranging from 2.0 to 16 µg/mL.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Aspergillus
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Água do Mar
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Microbiologia da Água
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Organismos Aquáticos
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Metabolismo Secundário
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Anti-Infecciosos
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article