K2S2O8-HFIP synergistically promoted para-selective sp3 C-H bond diarylation of glycine esters.
Org Biomol Chem
; 18(4): 666-670, 2020 01 28.
Article
em En
| MEDLINE
| ID: mdl-31894805
ABSTRACT
A metal-free K2S2O8-HFIP synergistically promoted double Friedel-Crafts alkylation between a glycine derivative and N-substituted aniline was developed to efficiently synthesize diarylmethane derivatives with high para-selectivity. The reaction proceeded smoothly in the absence of any metal and ligand, and exhibited a good tolerance of functional groups.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sulfatos
/
Compostos de Potássio
/
Propanóis
/
Ésteres
/
Glicina
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article