Cross-linking modifications of HDL apoproteins by oxidized phospholipids: structural characterization, <i>in vivo</i> detection, and functional implications.

Gao, Detao; Ashraf, Mohammad Z; Zhang, Lifang; Kar, Niladri; Byzova, Tatiana V; Podrez, Eugene A

Cross-linking modifications of HDL apoproteins by oxidized phospholipids: structural characterization, in vivo detection, and functional implications.

Gao, Detao; Ashraf, Mohammad Z; Zhang, Lifang; Kar, Niladri; Byzova, Tatiana V; Podrez, Eugene A.

Afiliação

Gao D; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Ashraf MZ; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Zhang L; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Kar N; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Byzova TV; Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195.
Podrez EA; Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio 44195. Electronic address: podreze@ccf.org.

J Biol Chem ; 295(7): 1973-1984, 2020 02 14.

Article em En | MEDLINE | ID: mdl-31907281

Assuntos

Apolipoproteína A-I/genética; Lipoproteínas HDL3/genética; Fosfolipídeos/genética; Receptores de LDL/genética; Animais; Aorta/metabolismo; Cromatografia Líquida; Humanos; Peróxido de Hidrogênio/metabolismo; Lipoproteínas HDL/genética; Macrófagos/metabolismo; Camundongos; Óxido Nítrico/genética; Óxido Nítrico/metabolismo; Oxirredução; Fosforilação Oxidativa; Fosfolipídeos/metabolismo; Espectrometria de Massas em Tandem

Palavras-chave

apolipoprotein; atherosclerosis; cardiovascular disease; cholesterol efflux; cross-linking; high-density lipoprotein (HDL); lipid metabolism; oxidative stress; oxidized phospholipid-apoprotein adduct; oxidized phospholipids; phospholipid metabolism

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfolipídeos / Receptores de LDL / Apolipoproteína A-I / Lipoproteínas HDL3 Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2020 Tipo de documento: Article

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