Rhodium-Catalyzed Enantioselective [4+2] Cycloadditions of Vinylcarbenes with Dienes.
Angew Chem Int Ed Engl
; 59(12): 4937-4941, 2020 03 16.
Article
em En
| MEDLINE
| ID: mdl-31910310
ABSTRACT
The reaction of 2-siloxycyclo-1,3-dienes with E-vinyldiazoacetates in the presence of the bulky chiral dirhodium tetracarboxylate catalyst, Rh2 (R-p-PhTPCP)4 results in an enantioselective [4+2] cycloaddition, in which three new stereogenic centers are formed. The [4+2] cycloadducts are generated as single diastereomers with high enantiocontrol (95-98 % ee). When the diene contains an additional stereogenic center, effective kinetic resolution can be achieved.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2020
Tipo de documento:
Article